TIME TABLE

TALK SCHEDULE

Opening Remark

10:00-10:10
Hidehiro Mizusawa (Tokyo Medical and Dental University, Japan)

Session1

“Stem cell and novel technologies”
chaired by Sang-Hun Lee (Hanyang University) Hideki Mochizuki (Osaka University)

10:10-10:35 “Human neural stem cell-based gene therapy for brain tumors”
Seung U. Kim1 and Hong J. Lee2 Medical Research Institute, Chung-Ang University College of Medicine, Seoul, Korea Department of Neurology, University of British Columbia, Vancouver, Canada

10:35-11:00 “Developmental information-based engineering of cultured neural stem cells for functional dopamine neuron generation”
Sang-Hun Lee Department of Biochemistry & Molecular Biology, College of Medicine, Hanyang University, Seoul, Korea

11:00-11:10 “Xeno-free defined culture conditions for generation of human induced pluripotent stem cells and neuronal differentiation induced from them”
Takumi Miura, Masakazu Machida, Akihiro Hosoda, Takashi Ohkura, Akihiro Umezawa and Hidenori Akutsu Department of Reproductive Biology, Center for Regenerative Medicine, National Research Institute for Child Health and Development, Tokyo, Japan

11:10-11:35 “Myelination in coculture of NGF-primed PC12 cells and immortalized adult Fischer rat Schwann cells (IFRS1)”
Kazunori Sango, Kazuhiko Watabe ALS/Neuropathy Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

11:35-11:45 “Establishment and characterization of human peripheral nerve microvascular endothelial cell lines: A new in vitro blood-nerve barrier (BNB) model”
Masaaki Abe1, Yasuteru Sano1, Toshihiko Maeda1, Fumitaka Shimizu1, Hiroyo Haruki1, Kazuyuki Saito2, Ayako Tasaki1, Motoharu Kawai1 and Takashi Kanda1 Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan. Department of Neurology and Neurological Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.

11:45-11:55 “Establishment of conditionally immortalized microvascular endothelial cells from rat spinal cord forming the blood-spinal cord barrier”

Toshihiko Maeda1, Yasuteru Sano1, Masaaki Abe1, Fumitaka Shimizu1, Yoko Kashiwamura1, Sumio Ohtsuki2,Tetsuya Terasaki2, Masuo Obinata3, Masatsugu Ueda4, Ri-ichi Takahashi4 and Takashi Kanda1 Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan, Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan, Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan, 4TheYS Institute, Inc., Tochigi, Japan

Break1 (lunch) 11:55-12:50

Session2

“Molecular pathology of neurological diseases”
chaired by Haeyoun Suh-Kim (Ajou University) Takao Takeshima (Tominaga Hospital)

12:50-13:15 “Molecular pathology of SCA6”
Hidehiro Mizusawa Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Center for Brain Integration Research, Tokyo, Japan

13:15-13:40 “Pathomechanisms of PQBP1 in neurons and neural stem cells causing learning defect and microcephaly”
Hitoshi Okazawa Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

13:40-14:05 “Non-cell autonomous therapeutic effects of Hsp40 on polyglutamine disease models via its exosome-mediated secretion”
Yoshitaka Nagai, Toshihide Takeuchi, H. Akiko Popiel, Keiji Wada Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan

14:05-14:15 “HMGB1 as a therapeutic molecule candidate for spinocerebellar ataxia type1”
Hikaru Ito, Keisuke Kurosu and Hitoshi Okazawa Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan

14:15-14:25 “Toxicity of non-coding pentanucleotide repeats causing spinocerebellar ataxia type 31 (SCA31), an autosomal dominant ataxia common in Japanese”
Yusuke Niimi, Kinya Ishikawa, Nozomu Sato and Hidehiro Mizusawa Department of Neurology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

Break2 (coffee) 14:25-14:40

Session3

“Molecular pathways in development”
chaired by Woong Sun (Korea University) Toya Ohashi (Jikei University)

14:40-15:05 “NeuroD, a proneural bHLH gene, relays metabolic signals to nuclei”
In-Su Cho1,2, Young-Guk Shin1, Seunghwan Jung1,2, Young-Don Lee1,3, Sung-Soo Kim1,4, Haeyoung Suh-Kim1,2,3 Departments of Anatomy, Neuroscience Graduate Program, BK21, Division of Cell Transformation and Restoration, Center for Cell Death Regulating Biodrug, Ajou University, School of Medicine, Suwon, Korea

15:05-15:30 “Suppression of Drp1 modulates survival of developing chick motoneurons during the period of normal programmed cell death”
So Yoen Choi, Joo Yeon Kim, Hyun-wook Kim, Bongki Cho, Hyun Kim, Im Joo Rhyu, Woong Sun Department of Anatomy, College of Medicine, Korea University, Seoul, Korea

15:30-15:55 “Organotypic hippocampal slice cultures for studies of postnatal neurogenesis”
Tatsunori Seki Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, Japan

15:55-16:05 “Analysis of the function of TSC1, a causative gene for tuberous sclerosis, in the formation of actin cytoskeleton and cell polarity.”

Maki Ohsawa1,2,3, Toshiyuki Kobayashi1,4, Hidehiro Okura1,5, Masashi Mizuguchi2, Okio Hino1,4 Dept. Pathol. Oncol., Juntendo Univ. Sch. Med., Tokyo, Japan, Dept. Dev. Med. Sci., Grad. Sch. Med., Univ. Tokyo, Tokyo, Japan, Dept. Pediatr., Grad. Sch. Med., Univ. Tokyo, Tokyo, Japan, Dept. Mol. Pathogenesis, Juntendo Univ. Grad. Sch. Med., Tokyo,Japan, Dept. Neurosurg., Juntendo Univ. Grad. Sch. Med., Tokyo Japan

Break3 16:05-16:10

Session4

“Pathology and cell signaling”
chaired by Sang Yoon Lee (Ajou University) Kosei Takeuchi (Niigata University)

16:10-16:35 “Regional cytoplasmic TDP-43　mislocalization is recapitulated in non-human primate model of ALS”

Takanori Yokota1, 　Mio Tajiri1, Takuya Ohkubo1, Azusa Uchida1, Hiroki Sasaguri1, Nobuyuki Kimura2, Toshiki Uchihara3, Hidehiro Mizusawa1 Dept of Neurology and Neurological Science, Tokyo Medical and Dental University, Graduate School of Medicine, Tokyo, Japan, Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Ibaraki, Japan, Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan

16:35-17:00 “LIPOPROTEIN LIPASE IS A NOVEL Aβ-BINDING PROTEIN THAT PROMOTES GLYCOSAMINOGLYCAN-DEPENDENT CELLULAR UPTAKE OF Aβ IN ASTROCYTES”
Makoto Michikawa Departments of Biochemistry, Nagoya City University, Graduate School of Medicine, Aichi, Japan

17:00-17:25 “Association of Membrane Phosphoinositide with Glial TLR4 Signaling”
Nguyen Thi Ngoc Tu, Yong Min Kim, Sang Yoon Lee Neuroscience Graduate Program, Chronic Inflammatory Disease Research Center, Ajou University, School of Medicine, Suwon, Korea

17:25-17:50 “Lipid-mediated axon guidance in the developing spinal cord”
Hiroyuki Kamiguchi RIKEN Brain Science Institute, Saitama, Japan

Closing Remark

17:50-18:00
Seung Up Kim (Chungang Universtity, Korea)

Reception will be held at ”18:00-19:30” in ”Grill Saints” (9th floor, Building1 west). Please join it! Fee 4000 Yen